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Life Sciences Report 2017 / 2018

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64 Life

64 Life Sciences Report – Biotech Companies Breecon GmbH The breecon GmbH is an innovative service company in life science with focus on green biotechnology. The objectives of the company are consulting, application and mediation of biotechnological-analytical services as well as their development and marketing. The breecon GmbH offers his services to plant breeders and companies of the industrial biotechnology and supports the utilization of genetic diversity in the context of SMART breeding. BST Bio Sensor Technology GmbH BST develops and produces biosensors to provide high quality analysis at moderate prices. In 1982 BST brought on the market the first multi-way biosensor based blood glucose analyzer in Europe and is since then market leader in Europe. Today BST sells more than 60.000 sensors a year. Since 2008 BST is besides biosensors also manufacturer of POCT and laboratory instruments. Caprotec bioanalytics GmbH Caprotecs Capture Compound Mass Spectrometry (CCMS) Technology allows separation and isolation of proteins based on functionality. For many applications, CCMS is clearly superior to conventional methods - thus addressing an unmet need in the proteomics research community. The company is commercializing the CCMS technology through ImproMed projects with pharmaceutical and biotechnology companies. The focus on these collaborations is on investigating mechanisms of drug action (MoA) and identification of on- and off-target proteins to understand potential adverse effects of drug candidates on a molecular level. This can be easily carried out in the lead optimization process, or even earlier to increase the probability of success later on in the clinic. Celares GmbH Specialist for Drug Delivery of peptides/proteins by using PEGylation. Modification of Biopharmaceuticals with polyethylene glycol in order to substantially improve pharmacological properties. Offers the unique CelaSYS- PEGylation technology, which is patented by celares. CelaSYS: non-dispersed, highly branched polyethylene glycol based reagents. Additionally celares offers customized PEGylation solutions as well as synthesis of customized PEG-reagents. Cellbricks GmbH Cellbricks developed a new Bioprinting technology which allows creating complex three-dimensional structures made of biological material. The company is specialized in Bioprinting services, creating tailor-made products to individual customer specifications - for example mini-organs for drug testing or tissues for regenerative medicine cultures as well as off the shelf products. With its profound experience Cellbricks empowers researchers to investigate functional human tissues for fundamental biological research or advanced regenerative therapies. CellDEG GmbH CellDEG GmbH applies its unique membrane aeration technology to highly efficient cultivation systems for microalgae. Optimal CO2 mass transfer rates into photosynthetic cultures result in highest growth rates, cell densities and natural product concentrations. CellDEG provides modular cultivation solutions that allow for fast and reliable production of biomass and is aiming to establish a new standard in lab scale and pilot scale cultivation to exploit the full potential of these organisms CellServe GmbH CellServe is a service provider for research groups in regenerative medicine and fills an important gap in the conversion of applied treatment concepts from research into marketable products. Furthermore CellServe develops own innovative cell-based products for cardiology and uses novel cardiac derived cells (“From the Heart to the Heart”) for the treatment of chronic heart failure. CellTrend GmbH Celltrend is certified according to ISO 9001, ISO 13485 and GMP Cell culture systems for research on active substances (bioassays, preclinical research, for quality control)Development and production of antibodybased detection systems (ELISA) Chemosensitivityassay for optimisation of chemotherapy (tumor patients). Centogene AG Centogene is a worldwide leader in the field of genetic diagnostic testing for rare hereditary diseases, with a broad test portfolio covering over 2800 genes, biochemical tests, biomarker and clinical whole exome sequencing and whole genome sequencing. Chemicell GmbH Chemicell develops and produces magnetic, fluorescent and coloured nano- and microparticles, reactive fluorescent dyes and special chromatography-materials for the separation or detection of cells, bacteria, viruses, proteins or DNA/RNA and new gene transfer systems. Chipron GmbH Chipron GmbH specializes in production and distribution of array based detection systems for DNA/pathogens.

Life Sciences Report – Biotech Companies 65 CHIRACON GmbH chiracon is a qualified partner to develop chiral intermediates at a constant high quality for innovative drugs regarding economic, environmentally acceptable and scaleable aspects. We offer support through expert knowledge and key technology to meet your increasing needs. Our core competence is chirality. In addition we have a broad variety of chiral building blocks as an inhouse raw material source for high-level API production and development. CMZ-Assay GmbH Marketing of diagnostic reagents for measuring concentrations of proteins, hormones and their isoforms, exclusively for research purposes. co.don ® AG CO.DON AG develops, produces and markets in Germany autologous cell therapies for the minimally invasive repair of cartilage damage in joints following traumatic or degenerative defects. The cell therapy product uses only the patient’s own cartilage cells (“autologous chondrocytes”) and has been used for more than 10 years in over 150 clinics to treat more than 11,000 patients. In Germany the statutory health insurance companies have paid for the treatment of knee and hip joints since 2007 and for the treatment of vertebral joints since 2008. In July 2017 the company received EU marketing authorisation for its articular cartilage product, which is to be distributed under the name of Spherox. The shares in CO.DON AG are listed on the Frankfurt Stock Exchange (ISIN: DE000A1K0227). CONGEN Biotechnologie GmbH CONGEN is specialized in food testing by molecular analytics based on DNA and RNA detection. CONGEN has been a pioneer for over a decade in the development and application of food and feed analytics by realtime PCR. The methods are available as complete analytic kit as well as a Service. Our mission is to serve the food industry with an excellent service and with standardized and reliable test kits in order to realize highest possible food safety and food quality. cpo - cellular phenomics & oncology Berlin-Buch GmbH cpo is a state-of-the-art in vitro service provider aimed at offering high-quality, reasonable priced cell culture models complementing classical in vivo assays using patient-derived 3D cell cultures. We view ourselves as partners with our customers, our employees, our scientific community and our environment. Our mission is to help the biotech and pharma industries create innovative testings of novel anti-cancer drugs. Cyano Biotech GmbH Cyano Biotech identifies and characterizes natural products from cyanobacteria and optimizes their pharmacological activities employing a biocombinatorial approach. The company conduct further development of identified lead structures till the preclinical phase. DendroPharm GmbH Dendropharms patented technology brings your drug to the target. We develop your API into a patentable new formulation. We offer formulation delivery services as well as full regulatory project management. DexLeChem GmbH We are experts in the reactivation of complex chiral catalysts. For the first time the unmodified homogeneous catalyst can be re-used repeatedly thanks to our innovative water based process. Supported by quantum chemical analysis we are able to simulate catalytic cycles. Combined with our special knowhow this enables us to find the best solvent system for our customers. By using this new resource-efficient reaction route our customers – manufacturers of active pharmaceutical ingredients (APIs) and fragrances – gain two advantages: reduction of production costs and a more sustainable process. Diaglobal GmbH Development, production and distribution of in vitro diagnostics for analytical purpose and the distribution of medical products. DIZG Deutsches Institut für Zell- und Gewebeersatz gemeinnützige GmbH DIZG German Institute for Cell and Tissue Replacement engages in cell and tissue preservation as well as in cell and tissue replacement, and provides tissue preparations of human origin to clinics, teaching and research organisations. Further service is culturing of skin cells (keratinozytes) for serious burns and other skin defects not healing well or affecting large areas. DIZG supplies cell cultures to help avoid experimentation with animals e.g. in the cosmetics industry. Dolopharm GmbH Conventional pain killers are limited by detrimental side effects. Opioids cause apnoea, sedation, constipation and addiction, and nonsteroidal analgesics can produce bleeding, ulcers, heart attacks and stroke. We design novel compounds that selectively activate peripheral opioid receptors at low pH in injured tissues, thereby precluding side effects in the brain and gut. Using our proprietary IN-SILICO-EVOLUTION (ISE) algorithm to analyse conformation dynamics of opioid receptor-ligand interactions, we designed the prototype NFEPP which produced potent analgesia without harmful side effects in preclinical in vitro and in vivo experiments

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