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Cluster Report Photonics in the Capital Region Berlin-Brandenburg

  • Text
  • Imaging
  • Photonics
  • Berlin
  • Optical
  • Laser
  • Technologies
  • Optics
  • Microsystems
  • Components
  • Brandenburg

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68 Cluster Report Optics and Photonics – Biophotonics and Ophthalmic Optics Brain imaging is a key technology in theoretical and clinical strokes research. To better address these problems, the Small Animal Imaging Center was opened at Charité’s Virchow campus in 2010. In addition to classical light microscopy, newly developed fluorescence tomography methods are used to investigate pathophysiological processes on animal models and to study the efficacy of new therapeutic approaches. The new center was made possible by the cooperation of Charité and industrial partners and driven by the Imaging Network Berlin. The network brings together academic institutions including the Charité, pharmaceutical companies, large-scale equipment manufacturers, and small and medium-sized enterprises from Berlin. All stakeholders agree that they see great potential in medical imaging for the medicine of the future. And with it for the Berlin Brandenburg region: both in terms of equipment and scientific excellence, the players represent the value-added chain of medical imaging. http://isolid.org Among others, the Biofilm Center of the German Heart Center Berlin is involved in this joint project. Specific - of biofilm-induced infectious diseases are possible using fluorescence in situ hybridisation (FISH). This diagnostic method is based on fluorescence-labelled DNA probes and combines the advantages of molecular biology, fluorescence microscopy, and histology. However, the FISH method uses very large amounts of image data, the analysis of which is complex and time-consuming. Within the framework of the iSOLID joint project, a digital method for image analysis will be developed to allow the automatic detection and quantification of microorganisms. www.dhzb.de/en/departments/cardiothoracic_and_ vascular_surgery/research/biofilm_center_of_the_ german_heart_center_berlin www.healthcapital.de/en/medical-technologies/portrait/ Diagnosis of biofilm infections The Imaging Network is not the only initiative in the region that is working on the development of optical methods for use in medicine by connecting companies and research institutions. DiagnostikNet-BB is bringing together diagnostics and equipment manufacturers, suppliers and users from clinics, and routine laboratories as well as research institutions in the Berlin Brandenburg region to promote innovations in the field of in vitro diagnostics. www.diagnostiknet-bb.de/en/ The Federal Ministry of Education and Research has set up the iSOLID joint project to develop an innovative digital image diagnostic system for the specific diagnosis of biofilm infections. Infectious diseases are among the ten most frequent causes of death in Europe. Many of these infections are caused by biofilm infections that are difficult to diagnose. The goal of iSOLID “Integrated Solutions for Infection Detection”) is the fast and reliable detection of such infections using digital image diagnostics and the recommendation of a suitable therapy. Optical technologies facilitate everyday life in wheelchairs. © Makea Industries GmbH Optical technologies in everyday life Optical technologies will also make an important contribution to better integration of people with disabilities. As part

Cluster Report Optics and Photonics – Biophotonics and Ophthalmic Optics 69 of the “Light Cares” competition, ten projects that make everyday life easier for people with disabilities were awarded prizes at FabLab Berlin in 2016. Many of these helpful ideas have come from the “maker scene”. Participants in this do-it-yourself movement, which is popular around the globe, use digital photonic manufacturing processes such as 3D printing and laser cutting. Two of the ten winners come from Berlin, one from Potsdam; the others are spread across Germany. Makea Industries GmbH from Berlin won two awards, one for its precision-fit prostheses made with a 3D printer, and the other for its freely producible products for wheelchairs. All in all, a digitally accessible open source solution has been created. Wissenschaftsladen Potsdam also won a prize with its project “Fabricate Your Living Aid and Digital e. V. Transformation of Laboratories”. www.bioprocess.tu-berlin.de/menue/joint_lab_bioelectronics Precise optical sensors are indispensable for determining the seriousness of tumours and the concentration of such substances as hemoglobin in blood. Several companies in Berlin Brandenburg is working on such devices, which will need to be reliable enough for everyday clinical use. This includes the photometer specialist ROBERT RIELE GmbH & Co KG as well as Chembio Diagnostics GmbH (former opTricon), which produces point-of-care diagnostic devices. www.riele.de www.chembiogermany.de/en www.fablab.berlin New Technologies for Medicine The gap between microelectronics and biotechnology has narrowed considerably in recent years, a process mainly driven by the fact that methods using nanoscale structures are being developed in both areas. Based on this convergence, the new field of bioelectronics has emerged. It addresses the integration of electronic systems into biological environments and investigates the interaction between these different material worlds. The most important developments are currently taking place in the field of biosensors where the increasing miniaturisation allows to integrate microsensors into biological or biotechnological systems. TU Berlin and the IHP – Innovations for High Performance Microelectronics operate a Joint Lab for Bioelectronics. The Fraunhofer Institute for Telecommunications, Heinrich Hertz Institute, HHI is also developing compact sensors for biomedical applications. These sensors contain silicon nitride chips, which are available in large numbers. They are highly sensitive and can quickly detect molecules in liquids, gases, and powders. All biological fluids such as blood serum, whole blood, urine, saliva, sweat, etc. can be analysed with this measuring principle. Even gases such as traces of explosives (TNT) or poison gas can be placed on the surface of the chips for analysis. In cooperation with the medical applications centre of the Charité, First Sensor AG and SCIENION AG are finding ways to bring this knowledge to market. www.hhi.fraunhofer.de/en/departments/pc.html In June 2017, Berlin-based start-up DiaMonTech GmbH won the prestigious “Start me up!” award of the business magazine BILANZ. The team led by Frankfurt biophysicist Werner Mäntele won for its non-invasive blood glucose measurement system. The device is currently still the size of a shoe box, but soon it will be reduced to the size of a watch that can be readily worn by patients. www.diamontech.de Biosensor implant encapsulated in silicone © IHP – Innovations for High Performance Microelectronics Berlin-based Humedics GmbH has specialised in the fast and precise measurement of liver function by analysing the air exhaled by patients. The test can be performed directly at the bedside and provides physicians with accurate information for therapeutic decisions on diseases involving liver

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