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Life Sciences Report 2017 / 2018

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38 Life

38 Life Sciences Report – Medical Imaging Medical Imaging The Berlin-Brandenburg region is among the best in the world for both “traditional” medical imaging and more experimental methods. More than 130 hospitals in Berlin and Brandenburg have a full range of equipment for large-scale diagnostic imaging at their disposal. A key feature of medical imaging in the German capital region is the close collaboration between scientists who conduct fundamental research in the fields of physics, biochemistry, bioinformatics and medicine, science, and industry. A modern and informative diagnosis is part of superior quality medical care, even before the patient receives treatment. In addition to determining vital signs, diagnostic imaging is an essential diagnostic element conducted using computer tomography (CT), magnetic resonance imaging (MRI) and ultrasounds. Ultrasound allows the physician to thoroughly assess tissues and structures inside the body, especially fluid-filled cavities. A computer tomography scan shows both soft areas and bone structures, while magnetic resonance tomography is especially well suited for imaging soft tissue and, unlike a CT, does not involve X-ray radiation. The use of contrast agents can improve imaging, and nuclear medical methods, such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), are increasingly gaining importance. Combining these with existing CT and MRI methods in a single device (MR-PET) is the technology of the future. This methodology makes it possible to generate reports on the patients’ anatomical situation on the one hand, as well as on physiological and pathological processes at the molecular level on the other. This means major diseases like cancer and different forms of dementia can be detected very early. SPECT is the preferred method for diagnosing circulatory disorders, and PET for cerebral metabolic disorders, e.g. when diagnosing Alzheimer’s disease or Parkinson’s disease. Imaging in cancer and neurology MRT, CT, and nuclear medical methods are used widely in the field of neurology. When treating a stroke, a CT scan is always preferred before a lysis is inserted into a clogged artery. Radioactive labeled substances are used to illustrate the function of the central nervous system in emission computed tomography SPECT and PET. These images show the brain in action and provide information on the metabolism of specific cerebral regions and on blood circulation. Imaging in cardiology Due to their high prevalence and life-threatening conditions, cardiovascular diseases are of particular interest in diagnostics and treatment. Science, clinics and industry work on these conditions collaboratively. In cardiology, the evolution of CTs and MRIs has advanced how rapidly moving coronary vessels are portrayed. At the same time, the amount of radiation they involve has been reduced. The most pronounced advantage of cardiac MRIs is that they combine high temporal and spatial resolution morphological and functional information. A key benefit of MRIs is the ability to characterize tissue so that, for example, inflammation of the heart muscle can be recognized at an early stage © GE Healthcare “From medical imaging, software & IT, patient monitoring, and diagnostics to drug discovery, biopharmaceutical manufacturing technologies, and performance improvement solutions, GE Healthcare helps medical professionals deliver great healthcare to their patients. With its innovative companies and a unique scientific landscape, Berlin- Brandenburg is an important region for us. Our academic cooperation with the Charité Berlin in CT imaging is a major milestone for GE Healthcare.” Arne Schmid General Manager GE Healthcare GmbH

Life Sciences Report – Medical Imaging 39 © Katharina Bohm/MDC The 3T Skyra of the national cohort. and quantitatively evaluated. Non-invasive imaging cardiac diagnostics will continue to gain importance compared to studies on invasive cardiac catheters. Diagnostic imaging – regional aspects The HealthCapital region is among the best in the world for both “traditional” medical imaging and more experimental methods. More than 130 hospitals in Berlin and Brandenburg have a full range of equipment for large-scale diagnostic imaging at their disposal, with more than 109 computer tomography scanners, 70 magnetic resonance imaging scanners, 68 coronary angiography locations and 9 positron emission computed tomography scanners. With the Institute of Radiology, the Clinic, the University Outpatient Clinic for Radiology and the Institute of Nuclear Medicine, the Charité, Europe’s largest university hospital, is also home to the largest radiology center on the continent. In addition to a center for pre-clinical small animal imaging, the doctors and researchers also have one of two scanners for magnetic particle imaging in Germany. Magnetic particle imaging (MPI) is currently being investigated by a small number of research groups around the world as a new method of medical imaging. For the moment, it is still limited to the spheres of research. This new type of imaging does not require X-rays. In addition, it offers the advantage that contrast agents based on iron oxide nanoparticles with a high level of sensitivity are immediately visible, contrary to indirect visibility in magnetic resonance imaging due to accelerated relaxation of water molecules. This means that quantitative imaging is possible and that the duration for acquiring the images is reduced, which is particularly important for images of the beating heart. A key feature of medical imaging in the German capital region is the close collaboration between scientists who conduct fundamental research in the fields of physics, biochemistry, bioinformatics and medicine, science and industry. The Experimental and Clinical Research Center (ECRC), a joint research institution of the Charité – Universitätsmedizin Berlin and the Max Delbrück Center for Molecular Medicine (MDC), forms a bridge between fundamental research and patient care, enabling research findings to be rapidly translated into treatment. Cardio-MRI is a focus of research and patient care in collaboration with Helios clinic. The Berlin Ultrahigh Field Facility (B.U.F.F.) provides the infrastructure for projects by an interdisciplinary imaging consortium

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