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Glycobiotechnology in Berlin-Brandenburg

  • Text
  • Pharma
  • Biotech
  • Berlin
  • Institute
  • Glycobiotechnology
  • Sciences
  • Technologies
  • Carbohydrates
  • Brandenburg
  • Diagnostics

6 Overview Map of

6 Overview Map of Regional Players Involved in Glycobiotechnology Overview Map of Regional Players Involved in Glycobiotechnology 5 17 18 16 25 24 34 3 4 8 28 31 20 2 Berlin 19 13 30 33 29 23 38 32 35 22 6 26 37 11 21 31 12 10 14 27 36 9 15 Brandenburg 7 1 Analyticon Discovery GmbH 2 BDW Berliner Diagnostik Werke GmbH 3 Berlin-Brandenburg Center for Regenerative Therapies 4 Beuth University of Applied Sciences Berlin 5 Biosyntan GmbH 6 biotechrabbit GmbH 7 Brandenburg University of Technology 8 Charité - Universitätsmedizin Berlin 9 Chiracon GmbH 10 evoxx technologies GmbH 11 Fraunhofer Institute for Applied Polymer Research 12 Fraunhofer Institute for Cell Therapy and Immunology - Potsdam-Golm location IZI-BB 13 Freie Universität Berlin 14 German Institute of Human Nutrition 15 Glycon Biochemicals GmbH 16 Glycotope GmbH 17 GlycoUniverse GmbH 18 HealthTwiSt GmbH 19 htw Berlin – University of Applied Sciences 20 Humboldt-Universität zu Berlin 21 Hybrotec GmbH 22 InVivo BioTech Services GmbH 23 JPT Peptide Technologies GmbH 24 Leibniz-Forschungsinstitut für Molekulare Pharmakologie 25 Max Delbrück Center for Molecular Medicine Berlin-Buch 26 Max Planck Institute for Colloids and Interfaces 27 Medipan GmbH 28 MicroDiscovery GmbH 29 Octapharma Biopharmaceuticals GmbH 30 PlasmaChem GmbH 31 ProBioGen AG 32 Proteome Factory AG 33 Scienion AG 34 Technische Universität Berlin 35 UGA Biopharma GmbH 36 University of Applied Sciences Wildau 37 University of Potsdam 38 Vaxxilon GmbH

Key Areas of Research and Development – Advancements in Healthcare Will Be Sweet 7 Key Areas of Research and Development – Advancements in Healthcare Will Be Sweet Berlin and Brandenburg have built a strong expertise in glycosciences and glycobiotechnology and the results of research efforts enjoy worldwide recognition in the scientific community. At the same time, an increasing trend is visible in which research results are being transferred to applications and practice. Universities, research institutes and companies cover the whole value chain from basic and applied research to developing and commercializing products. Having evolved from a specialist’s discipline, glycosciences and glycobiotechnology have become integral areas of research in various areas of life sciences such as biology, biochemistry, medicine, pharmacology as well as other science specialties like material sciences or energy production. While the tremendous impact of glycans in all living beings is undisputed today, deciphering its innumerable functions and unraveling its complex structures remains a gigantic task. Glycoanalytics addresses both, analyzing the structure of carbohydrates as part of glycoconjugates and their function in health and disease. Altered glycosylation patterns can be associated with many diseases and these findings are leading to a new class of glycan-based biomarkers which can be used for novel diagnostics. R&D activities utilizing glycoengineering technologies primarily aim at creating and improving glycoprotein drugs or carbohydrate-based vaccines by rational design. Other regional research activities focus on research on rare hereditary diseases known as Congenital Disorders of Glycosylation (CDG) which are characterized by a variety of glycosylation anomalies. Uwe Kornak and his group at the Institute for Medical Genetics and Human Genetics, Charité – Universitätsmedizin Berlin, investigate the Golgi compartment as the most important site for posttranslational protein modifications. Mutations in Golgi proteins have been detected in patients with CDG of variable severity. Uwe Kornak is a member of the E-Rare research project EURO-CDG-2 on molecular diagnostics, mechanisms and treatment of CDGs. Further research involves multidisciplinary approaches and includes projects in bioinformatics, polymer sciences, nutrition and plant glycobiotechnology. “Glycobiotechnology is a growing field in research on the role of glycans and development of applications utilizing sugar molecules in therapy, diagnostics and functional food. Many small and medium enterprises and academic institutions in the Berlin-Brandenburg area are focusing on the production of biosimilars of established glycopharmaceuticals as well as on the development of biobetters for improved medical application. This includes therapeutic antibodies, recombinant clotting factors, inflammation inhibitors and vaccines. New methods for glyco-based diagnostics are also important issues in the rapidly expanding field of glycobiotechnology.” Stephan Hinderlich Professor of Biochemistry, Beuth University of Applied Sciences Berlin, Department Life Sciences and Technology

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