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Cluster Report Photonics in the Capital Region Berlin-Brandenburg

  • Text
  • Imaging
  • Photonics
  • Berlin
  • Optical
  • Laser
  • Technologies
  • Optics
  • Microsystems
  • Components
  • Brandenburg

5.1.4 Optical Technology

5.1.4 Optical Technology in Biomedicine and Pharmaceuticals Such procedures are being researched in the region: In a cooperation of World of Medicine with the Vivantes Hospital Neukölln, for example, FOVIS was developed – a method for visualization of the lymphatic system using a newly designed fluorescent camera. Also, the fluorescent dye indocyanine green is injected into the tissue surrounding a tumor. Via an LED light source, the camera system activates fluorescence and displays it in real time with a superimposed color image. This way, for example, lymphatic ducts and, thereby, propagation paths of metastases can be visualized. Endoscopic applications are conceivable in this area, too. In the future, even specific molecules could be designed which, introduced into the body, could act as a tumor marker. Developing these fluorescent peptide probes is the goal of the project “Optosample”. The vision is that one day such probes will show the surgeon during surgery which tissue function is pathologically modified and must be removed. In this context it is important to clarify how such molecules should be constructed in terms of binding constant, chemical stability and responsiveness. As a Berlin-based partner, LMTB is participating in this project funded by the Federal Ministry of Science and Research; LMTB’s task is to develop a fluorescence-optical readout system for the determination of the binding kinetics of probes. hand, the Fraunhofer-Institute for Reliability and Micro Integration (IZM) is part of the development of small single-use cameras that can be used at the tip of endoscopes. In a segment shorter than a millimeter, they combine optics and sensor, so that the entire camera can be mounted at the top of even small endoscopes. In Berlin-Brandenburg, also endoscopy with a 360-degree panoramic view is being worked on: A partner in the project endoguide is the Berlin Fraunhofer-Institute for Computer Architecture and Software Technology (FIRST). They develop a virtual prototype and intuitive control software for the upcoming panoramic endoscopy, funded by the Federal Ministry of Science and Research. Optics aid minimally-invasive surgery In other fields, similar types of diagnostics are already in practical use: the Berlin W.O.M. World of Medicine, for example, offers a tool for the detection of lymph nodes affected by cancer – the “gamma scanner” which responds to the emitted gamma radiation of tumor cells, is the only handheld probe on the market able to do this. W.O.M. is one of the pioneers of minimally invasive surgery and is now one of the world market leaders for the required components. In the optical range, their portfolio includes coldlight sources, medical cameras and laser systems that can be used – inter alia – for stone fragmentation. Micro camera in medical environment © Fraunhofer IZM/Awaiba GmbH From pharmaceuticals to myocardial infarction – analysis technology from the region Not only research is done in the region in terms of medical endoscopy and optical analysis, but also production. For example, the Berlin company Scopis develops and markets laser-based endoscopic navigation and measurement systems for minimally invasive surgery, which are used – among other fields – in otolaryngology. Scopis systems work with augmented realitiy, i.e. they allow preoperative planning of anatomical structures and their intraoperative insertion directly into the endoscopic image. Autoclavable 3-chip camera head © W.O.M. World of Medicine AG W.O.M. continues to drive the development. An example is a project aiming to develop endoscope technology and cameras for minimally invasive surgery at the open magnetic resonance tomograph. In this area, W.O.M. cooperates with the endoscopy specialists MGB Endoskopische Geräte and the Charité; the project is funded by the Berlin innovation program ProFIT. On the other Operating room use of MATRIX POLAR – System © Scopis GmbH 68

5.1.4 Optical Technology in Biomedicine and Pharmaceuticals XION, also from Berlin, offers complete endoscopy systems for various areas of minimally invasive surgery, endoscopes, cameras and lighting systems, as well as software for analyzing, processing and archiving. And the Karlheinz Gutsche GmbH produces microoptical components for endoscopes. Innovative Optische Messtechnik (IOM), which also is located in Berlin, is working on analysis techniques for fluorescence spectroscopy and tissue diagnosis. They offer fiber-optic fluorescence spectrometers with nanosecond time resolution; IOM technology can also be used for highly selective metabolic analysis in tissue and cell cultures. Rap ID provides measurement technology for Raman spectroscopy and laser-induced breakdown spectroscopy (LIBS), not least for use in pharmaceutical and life sciences. Nano Bio Analytics specializes in optical spectrographs, process Raman systems and micro-particle sensor systems. The Potsdam start-up Colibri Photonics develops and manufactures optical sensor systems for measuring oxygen. Spherical micro probes are admixed to the cellular tissue, which show optically the oxygen content by their phosphorescence. The signals are measured and analyzed by the Colibri Photonics hardware. In this manner, a three dimensional image of the oxygen distribution can be created. Thus, the distribution of oxygen can be precisely controlled during the growth process and adapted to the different requirements of different cells by appropriate control mechanisms. The Berlin-Brandenburg companies share the high level of innovation and strong orientation towards research and development. Scientific work and practical application are very close, for example at Optricon. This Berlin-based company provides development services in the areas of laser-based point-of-care diagnostics and optical bioanalytics. They developed an optical tester that can be used directly in the ambulance to determine if a patient has suffered a heart attack. The compact unit operates with test strips and analyzes the presence of certain marker substances - the world's fastest test for heart attack, which is distributed by 8sens Biognostic. Together with the Institute of Chemistry of the University of Potsdam, Optricon develops a compact laser fluorometer as an add-on module for fluorescence microscopy, with which the oxygen content of living cells can be determined. LUMiSizer © L.U.M. GmbH Light cuts and ablates – lasers in medicine For the surgeon, light can not only provide guidance. It may also be a direct tool – especially the laser, which is used in more and more operations. Newport Spectra-Physics, one of the largest companies in the world in this area, has a German subsidiary in Stahnsdorf in Brandenburg. In Stahnsdorf, primarily diode-pumped solid state lasers are developed and produced. In addition to industrial use, their application areas are in life and health science, microscopy and biotechnology. By controlling thermal effects the operating mode LFD (Levelled Field Density) reduces damage of surrounding tissue © Limmer Laser GmbH Measurements of oxygen distribution in cartilage cells © Colibri Photonics GmbH L.U.M. GmbH is one of the world's leading manufacturers of equipment for direct and fast stability analysis and particle characterization of dispersions, for example in the pharmaceutical industry. The Berlin company Limmer Laser specializes in the development and manufacture of medical lasers. The company's products are used in almost all disciplines of human, dental and veterinary medicine, the portfolio ranges from traditional CO2 lasers via diode lasers to special equipment. They offer the first high-power diode lasers which is approved for medical use. The Diolas LFD Advanced can be used, for example, for the treatment of tumors in the bladder or for indications concerning thorax and abdomen. In addition, they currently work, together with the Charité, on lasers which should be capable to treat cancer in narrow hollow organs such as urinary tract, prostate, and intestine sections as well as in the uterus, minimally invasive and gentler than before – a research project for which the partners already received an award from the Federal Ministry of Economics and Technology. 69

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