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Cluster Report Photonics in the Capital Region Berlin-Brandenburg

  • Text
  • Imaging
  • Photonics
  • Berlin
  • Optical
  • Laser
  • Technologies
  • Optics
  • Microsystems
  • Components
  • Brandenburg

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66 Cluster Report Optics and Photonics – Biomedical and Ophthalmic Optics A completely new acceleration model has been developed over the past years: at the laser wakefield acceleration, a high-intensity laser pulse is chased into a suitable plasma. The result is a small wave that moves quickly through the plasma and in which enormous electric field strengths prevail. This in turn accelerates the electrons in the plasma to high energies. This technology offers the possibility of building particle accelerators for protons or ions in much smaller spaces than were previously needed. Scientists at the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy, among others, are working on devices that will enable precise tumour radiation in the future. www.mbi-berlin.de Bioanalytics The precise analysis of chemical compounds, biological macromolecules, cells, and microorganisms is an important task in many areas of science, industry, and medicine. Typical technologies are micro- and spectroscopic methods. Highperformance liquid chromatography (HPLC) with UV fluorescence detectors is particularly popular to analyse a large number of biological samples. One example is KNAUER Wissenschaftlicher Gerätebau GmbH. KNAUER’s main business is the development and production of liquid chromatography systems. The product portfolio includes UHPLC systems, biochromatography systems, and sample preparation systems. The HPLC solutions offered for sample purification range from preparative HPLC to simulated moving bed (SMB) chromatography. www.knauer.net Automation also plays an important role in medical technology or the pharmaceutical industry. This includes, for example, pipetting tasks or the optical analysis of biological samples. The CytoFa analysis system from pi4_robotics GmbH combines robot-based liquid handling with automated image acquisition of biological samples in a compact laboratory device. The CytoFa contains a mororised microscope with a high-resolution camera and a 3-axis robot with an additional rotary axis for liquid handling. Due to its spatial isolation and integrated temperature control, CytoFa is particularly suitable for the handling of light- and temperature-sensitive materials. Depending on the microscope configuration, various illumination and contrast methods can be set in the control software and integrated into the automated process. With this methods fluorescence images of biological samples can be provided, for example. www.pi4.de The Ferdinand-Braun-Institut, Leibniz-Institut fuer Hoechstfrequenztechnik (FBH) develops laser beam sources for Raman spectroscopy. These include diode lasers that emit light with two wavelengths at a fixed distance of about 1 nm from a chip. This makes them ideal for “Shifted Excitation Raman Difference Spectroscopy (SERDS)”. SERDS allows Raman signals to be separated from interfering backgrounds such as fluorescence or ambient light. In combination with micro-optics, the lasers come in small sizes, allowing mobile applications in medicine. FBH uses this technology, among other things, to provide beam sources in the yellow wavelength range. www.fbh-berlin.com In 2003, sglux GmbH was founded by scientists and technicians working in the field of optical semiconductor development. They are experts in UV radiation and produce components for measuring ultraviolet (UV) radiation. In addition to waterworks, the beverage industry is one of sglux’s customers. However, the sensors are also used in dialysis machines, to monitor heating burner flames, and to measure the UV portion in the sun’s rays. sglux is also a member of the UV For Life Consortium, which addresses the development of UV LEDs (see chapter 4.2 “Lighting Technology”). www.sglux.de/en CytoFa laboratory device for robot-based liquid handling © pi4_robotics GmbH Mobile analysis technology is also being developed at the Fraunhofer Institute for Reliability and Microintegration IZM. The RF-KombiSCAN is able to determine the quantity and composition of various substances by their different

Cluster Report Optics and Photonics – Biomedical and Ophthalmic Optics 67 irradiation wavelengths. This new, portable, handheld optical measuring device radically simplifies and accelerates measurement procedures by integrating fluorescence and Raman spectroscopy. The mobile scanner can be used both as a laboratory research device and in industrial applications. www.izm.fraunhofer.de/en.html Fluorescence in vivo Imaging The principle of fluorescence in-vivo imaging is based on the properties of fluorescent dyes which are in the excited state when irradiated with certain wavelengths and emit fluorescence to return to the ground state. greateyes GmbH, a Berlin specialist for high-resolution cameras, offers a camera that is particularly sensitive in near-infrared to record these emissions. Fluorescence in vivo imaging is used, for example, in detecting the presence of cancer cells in lymph nodes. An intravenously applied dye is absorbed by the lymph node tissue. The detection of the weak fluorescence penetrating the tissue requires a highly sensitive camera and the aid of a special filter. www.greateyes.de/en RF-KombiSCAN as laboratory device © Fraunhofer IZM Chemical reactions and separation operations in liquid systems are often diffusion-controlled. A reduction of the reaction systems (“lab-on-a-chip”) can therefore significantly reduce the reaction time and also the sample consumption and thus greatly simplify medical analyses. Microchips with a total size of only a few square centimetres open up the possibility of integrating several functional reaction units in a very small space. At the Leibniz-Institut für Analytische Wissenschaften – ISAS e. V., corresponding methods and structures are being researched. In combination with fast and sensitive detection methods, a fully miniaturised total analysis system (µTAS) can be set up to automate sample injection, separation, and detection. Time-resolved optical nanoscopy The Department for Bioenergetics at TU Berlin’s Institute of Chemistry applies microscopy and spectroscopy, electrophysiological methods, and their combination with optical methods to living cells. Wide-field fluorescence microscopy with high spatial and time resolution single photon detectors for multichannel FLIM measurements enable spatially resolved microscopy of dynamic processes and simultaneous fluorescence correlation spectroscopy in each pixel with 100 ps temporal resolution and a measurement duration of 10 µs. These techniques overcome previous limits in precision, parallelisation, and speed. They have a particularly high application potential in industrial projects, in pharmaceutical drug research, and cell-based diagnostics. www.bioenergetik.tu-berlin.de/menue/bioenergetik/parameter/en/ www.isas.de/en Scattered light image (left), superimposed with the fluorescence signal on the GE 1024 1024 DD NIR camera (right) © greateyes GmbH

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