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Cluster Report Photonics in the Capital Region Berlin-Brandenburg

  • Text
  • Imaging
  • Photonics
  • Berlin
  • Optical
  • Laser
  • Technologies
  • Optics
  • Microsystems
  • Components
  • Brandenburg

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60 Cluster Report Optics and Photonics – Research & Industry | Biomedical and Ophthalmic Optics 2.5 Biomedical and Ophthalmic Optics – Photonics in Life Sciences Whether prevention, diagnostics, therapy, or analytics: without optical methods, modern medicine could only achieve a part of what it is now capable of. Reliable diagnostics are essential in medicine in order to achieve therapeutic success. The precise analysis of chemical compounds, biological macromolecules, cells, and microorganisms has enabled many new insights in recent years. Microscopy and spectroscopy are the cornerstones of this progress. Nowadays, more samples can be analysed thanks to new methods in fluorescence microscopy. The 2014 Nobel Prize in Chemistry was awarded to William Moerner, Eric Betzig, and Stefan Hell (Director at the Max Planck Institute for Biophysical Chemistry in Göttingen), demonstrating the groundbreaking character of these developments. This has opened up a completely new area beyond the resolution limit in microscopy not only providing impulses in research but also changing medical practice in future. “There are many new developments and trends, especially in optical technologies. Laser technology has become an indispensable part of ophthalmology, there are new imaging methods and optical measuring methods, and we are training the needed specialists herein in Berlin Brandenburg.” Prof. Dr. Justus Eichstädt | Spokesperson Focus Area Biomedical and Ophthalmic Optics, TH Brandenburg and Chairman of the Board of Laserverbund Berlin-Brandenburg e. V. Research and Healing Optical technologies in dermatology and cancer therapy As the most research-intensive hospital in Germany, Berlin’s Charité is very interested in testing new optical and photonic technologies. Such new technologies can be implemented particularly quickly in fields like dermatology, since these methods do not work endoscopically and do not need to be miniaturised. Scientists and doctors at the Center of Experimental and Applied Cutaneous Physiology (CCP) are investigating basic dermatological questions as well as new medical applications. www.ccp-berlin.org Optical and photonic methods now play a decisive role in almost all research projects. The team led by Prof. Jürgen Lademann (Head of the CCP) was for the first time successful in using modern spectroscopy to show that nanoparticles can also be absorbed by hair follicles. A new field seeing tremendous growth internationally is using cold plasmas to heal wounds. Such plasmas approximate skin temperature and have great potential to disinfect protracted wounds and enable the healing process to start. Here, too, spectroscopic methods are playing a decisive role in characterising the entire process. Using Raman resonance spectrometry, the researchers led by Prof. Lademann were able to quantify harmful excretions of chemotherapeutics in cancer patients via the skin. This enables new treatment methods for this often very unpleasant side effect of chemotherapy. https://derma.charite.de/en/metas/person_detail/person/ address_detail/lademann/ Protecting oneself from the sun’s rays is a particularly important step in preventing malignant skin cancers. Absorption spectra were used to determine that not only UV radiation is harmful. Longer wavelength components in the visible and infrared light can also increase stress on the skin by increasing the number of free radicals. Magnosco GmbH offers an optical analysis method for malignant skin cancer, allowing non-invasive and painless examination of atypical and dysplastic skin lesions. Magnosco was founded in 2014 by LTB Lasertechnik Berlin. LTB had developed the method for the early detection of

Cluster Report Optics and Photonics – Biomedical and Ophthalmic Optics 61 melanomas which uses infrared laser light to excite the skin pigment melanin. Fluorescence allows the early detection of the molecular structure of melanomas. www.magnosco.com/home Multiphoton tomography from JenLab GmbH, now also based in Berlin, offers non-invasive, marker-free in vivo examination of the skin with the highest spatial and temporal resolution to date. Intra- as well as extracellular structures can be investigated with a resolution of only 300 nm within seconds on the screen. This is due to clinical multiphoton tomography, a new form of high-resolution imaging using femtosecond lasers. This allows individual mitochondria, melanosomes, and cell nuclei as well as the elastin and collagen network to be mapped three-dimensionally in situ without any staining. ography (PET) with corresponding radioactively labelled tracer substances enables non-invasive quantitative characterisation of physiological and pathological processes in the organism with high sensitivity, e.g. for the diagnosis of tumours, neurodegenerative diseases including brain perfusion measurements, infections, and metabolic diseases such as bone metabolism disorders. The BERIC, partly funded by the German Research Foundation and the Future Fund of the State of Berlin, is equipped with a modern high-resolution small animal SPECT/CT (nanoSPECT/ CT plus, Bioscan/Mediso) and a state-of-the-art small animal PET/MRT (PET/MRI, Mediso). The BERIC is generally available as a core facility for external academic working groups as well as for contract research. https://www.charite.de/en/research/research_support_ services/forschungsinfrastruktur/imaging/ www.jenlab.de a b c Multi-photon tomographs can perform optical skin biopsies within seconds © JenLab GmbH Both nationally and internationally, the Charité plays a pioneering role in medical imaging. Thanks to its excellent equipment, the imaging value chain is almost completely covered, supporting scientific excellence and collaborative projects. a) SPECT/CT of a mouse with sodium iodide symporter (NIS-)transfected subcutaneous tumour (Tc-99m pertechnetate uptake) b) Tc-99m MDP skeletal scintigraphy of a mouse (left) and quantification c) PET/MRT of a rat with liver tumour (below: FDG uptake) © Berlin Experimental Radionuclide Imaging Center, Charité Universitätsmedizin – Berlin The Berlin Experimental Radionuclide Imaging Center (BERIC) as the core facility of the faculty, together with the Clinic for Nuclear Medicine, offers all modalities of modern hybrid imaging of experimental animals with radiopharmaceuticals. Molecular imaging using single-photon emission computed tomography (SPECT) and positron emission tom-

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